Velocity and attenuation of sound in arterial tissues

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Abstract
The velocity and attenuation of sound was determined for freshly excised human and canine arterial tissues using a time delay spectrometer (TDS) technique. Frequency was swept from 0 to 10 MHz with data taken in the range of 2-10 MHz. The velocity was determined using a comparison of the time delay for the received signal between a water path and a sample tissue of measured thickness. The velocity of sound was measured for various pathologies and related to biochemical assays of tissue. It increased with increasing ultrasound attenuation of the tissue. The velocity increased with increased collagen, C, expressed as a percentage of wet wt of the tissue, [V = 17.8*C + 1561 m/s at 37.degree. C, r = 0.77], but was not strongly dependent on tissue cholesterol or low levels of Ca. For highly calcified lesions, the velocity of sound was .apprx. 2000 m/s at 37.degree. C.

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