A nuclear RNA‐binding cyclophilin in human T cells
- 2 December 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 398 (2-3) , 201-205
- https://doi.org/10.1016/s0014-5793(96)01248-3
Abstract
Cyclophilins (CyPs) are binding proteins for the immunosuppressive drug cyclosporin A (CsA). CyPs are evolutionarily highly conserved proteins present in both pro-and eukaryotes as well as in different subcellular locations. Cyps possess enzymatic activity, namely peptidyl-prolyl cis-trans isomerase (PPIase) activity; CyPs are involved in cellular protein folding and protein interactions. To date, only cyclosporins and proteins are known to interact with CyPs. Here we describe a novel nuclear cyclophilin (hCyP33) from human T cells with an additional RNA-binding domain. This combines for the first time RNA binding and protein folding in one protein.Keywords
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