Effect of truncal vagotomy on gastroduodenal content of gastrin
- 1 January 1977
- journal article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 64 (1) , 34-38
- https://doi.org/10.1002/bjs.1800640109
Abstract
The vagal influence on gastroduodenal content of gastrin was studied in duodenal ulcer patients. Endoscopic biopsies were assayed for total concentrations of gastrin, and fractionated for measurements of gastrin components before and after total vagotomy. Antral concentration was 17.0±2.0 μg gastrin/g mucosa (mean±s.e.m.) in 52 unoperated patients compared with 25.2 ± 3.2 μg in 32 vagotomized patients. In 14 patients studied before and 3 months after vagotomy antral content was almost doubled (10.9 ± 2.3 and 20.4 ± 2.9 μg respectively). In the duodenal bulb the concentration was 2.4 ± 0.3 μg in 37 unoperated patients and 2.2 ± 0.4 μg in 19 vagotomized patients. In 6 patients in whom measurements were made throughout the duodenum, gastrin concentrations were slightly but significantly lower 3 months after vagotomy. Fractionations of pooled homogenates on Sephadex G-50 showed that gastrin component III (gastrin-17) made up 95 per cent of the antral gastrins before and after operation. In the duodenum component III constituted more than half of the gastrins preoperatively but only one-third postoperatively. The total amount of gastroduodenal gastrin was considerably increased by vagotomy, and it is well established that in serum the gastrin concentration is also higher postoperatively. The most likely implication of these findings is that in man the vagus, directly or indirectly, suppresses gastrin production.Keywords
Funding Information
- Fonden til Lægevidenskabens Fremme
- Forskningsfonden for Færøerne, Storkøbenhavn og Grønland
This publication has 5 references indexed in Scilit:
- Concentration and component pattern in gastric, duodenal, and jejunal mucosa of normal human subjects and patients with duodenal ulcerGastroenterology, 1976
- Gastrin response to food in duodenal ulcer patients before and after selective or highly selective vagotomyBritish Journal of Surgery, 1974
- Determination of Gastrin in SerumScandinavian Journal of Gastroenterology, 1973
- Preparation of125I-Labelled Synthetic Human Gastrin I for RadioimmunoanalysisScandinavian Journal of Clinical and Laboratory Investigation, 1972
- Production and Evaluation of Antibodies for the Radioimmunoassay of GastrinScandinavian Journal of Clinical and Laboratory Investigation, 1972