A comparison of adenine and some derivatives on pig isolated tracheal muscle

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Abstract
The muscle relaxation induced by adenine and several adenine derivatives in strips of tracheal smooth muscle from pigs was studied in addition to their metabolism by the tissue. Adenine relaxed tissue which was contracted by carbachol, histamine, or KCl. Adenine''s potency was similar to that of adenosine and ATP (threshold about 4 .times. 10-5 M). In tissues with carbachol-induced tone, the adenine effect differed from adenosine and ATP by being slower in onset and in washout time. Neither dipyridamole nor theophylline modified the response to adenine. The relationship was examined between pharmacological effects and the metabolism of [3H]-adenosine, and [3H]-adenine. Both substrates were taken up by the tissue and converted to nucleotides, but relaxation correlated with nucleotide accumulation only in the case of [3H]-adenine. The site and mechanism of adenine-induced relaxation is evidently different from that of adenosine and ATP in porcine tracheal muscle.