Increased risk of urothelial cancer in Stockholm during 1985‐87 after exposure to benzene and exhausts

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Abstract
In a population-based case-referent study of urothelial cancer in Stockholm during 1985–87, information was obtained from 80% of 320 identified male cases and 79% of 363 selected male referents. Industrial exposures were assessed for each subject by an industrial hygienist on the basis of questionnaire data. Exposure to benzene (any annual dose) gave a relative risk (with 95% confidence interval) of 2.0 (1.0–3.8). The highest risk was seen for a high annual dose. Subjects exposed to both diesel and petrol exhausts (moderate/high annual dose) had a relative risk of 7.1 (0.9–58.8). However, adjusting for benzene changed the relative risk to 5.1 (0.6–43.6). It might be rewarding to consider whether benzene from petrol confounds the associations previously suggested between exhausts and urothelial cancer. Exposure to polychlorinated biphenyls (PCB) gave a relative risk of 3.3 (0.6–18.4).