Clinical trial of indomethacin in Alzheimer's disease
- 1 August 1993
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Neurology
- Vol. 43 (8) , 1609
- https://doi.org/10.1212/wnl.43.8.1609
Abstract
In a 6-month, double-blind, placebo-controlled study, 1100 to 150 mg/d indomethacin appeared to protect mild to moderately impaired Alzheimer9s disease patients from the degree of cognitive decline exhibited by a well-matched, placebo-treated group. Over a battery of cognitive tests, indomethacin patients improved 1.3% (±1.8%), whereas placebo patients declined 8.4% (±2.3%)—a significant difference (p < 0.003). Caveats include adverse reactions to indomethacin and the limited scale of the trial.Keywords
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