Recent advances in array comparative genomic hybridization technologies and their applications in human genetics
Open Access
- 16 November 2005
- journal article
- review article
- Published by Springer Nature in European Journal of Human Genetics
- Vol. 14 (2) , 139-148
- https://doi.org/10.1038/sj.ejhg.5201531
Abstract
Array comparative genomic hybridization (array CGH) is a method used to detect segmental DNA copy number alterations. Recently, advances in this technology have enabled high-resolution examination for identifying genetic alterations and copy number variations on a genome-wide scale. This review describes the current genomic array platforms and CGH methodologies, highlights their applications for studying cancer genetics, constitutional disease and human variation, and discusses visualization and analytical software programs for computational interpretation of array CGH data.Keywords
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