REGULATION BY PROTEIN KINASE C OF TRANSFORMING GROWTH FACTOR‐β1 ACTION ON THE PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS FROM SPONTANEOUSLY HYPERTENSIVE RATS
- 1 July 1996
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 23 (6-7) , 573-575
- https://doi.org/10.1111/j.1440-1681.1996.tb02783.x
Abstract
1. This study examined the role of protein kinase C (PKC) on the action of transforming growth factor-beta 1 (TGF-beta 1) to regulate the proliferation of vascular smooth muscle cells (VSMC) isolated from the aorta of the spontaneously hypertensive rat (SHR). 2. Down-regulation of PKC by prolonged exposure to phorbol 12-myristate 13-acetate (PMA) completely inhibited the ability of TGF-beta 1 to potentiate epidermal growth factor-stimulated proliferation of VSMC. 3. In contrast, the inhibitory effect of TGF-beta 1 on serum-stimulated proliferation of VSMC was not altered by PMA action. 4. These results suggest that PKC-dependent signalling pathways involved in the regulation of growth by TGF-beta 1 may be important in any proliferative component of vascular hypertrophy that develops in the SHR.Keywords
This publication has 16 references indexed in Scilit:
- TGF-β: receptors and cell cycle arrestMolecular and Cellular Endocrinology, 1996
- Developmental regulation of transforming growth factor-??1 responses and vascular smooth muscle growth in spontaneously hypertensive ratsJournal Of Hypertension, 1995
- High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cellsKidney International, 1995
- Transforming growth factor-beta 1 gene activation and growth of smooth muscle from hypertensive rats.Hypertension, 1994
- The TGF-β family and its composite receptorsTrends in Cell Biology, 1994
- Enhanced Phospholipased Activity in Vascular Smooth Muscle Cells Derived from Spontaneously Hypertensive RatsClinical and Experimental Hypertension, 1994
- Differences in growth characteristics of vascular smooth muscle from spontaneously hypertensive and Wistar???Kyoto rats are growth factor dependentJournal Of Hypertension, 1993
- Protein kinase C of smooth muscle.Hypertension, 1992
- The phosphoinositide signaling system and hypertensionCurrent Opinion in Nephrology and Hypertension, 1992
- Vascular smooth muscle growth in genetic hypertensionJournal Of Hypertension, 1992