Metabolism in Vitro of Enflurane, Isoflurane, and Methoxyflurane
- 1 April 1975
- journal article
- research article
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 42 (4) , 420-424
- https://doi.org/10.1097/00000542-197504000-00010
Abstract
Specific activities of enflurane, isoflurane, and methoxyflurane defluorinases were measured in microsomes prepared from the livers of Fischer 344 rats; the ratio of these activities was 23:3:1. Pretreatment with phenobarbital significantly increased the defluorinase activities of all three agents. Factors that influence anesthetic drug metabolism are discussed; tissue solubility is considered to be the most important.Keywords
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