The Relation between Insulin Sensitivity and the Fatty-Acid Composition of Skeletal-Muscle Phospholipids
- 28 January 1993
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 328 (4) , 238-244
- https://doi.org/10.1056/nejm199301283280404
Abstract
Insulin resistance and hyperinsulinemia are features of obesity, non-insulin-dependent diabetes mellitus, and other disorders. Skeletal muscle is a major site of insulin action, and insulin sensitivity may be related to the fatty-acid composition of the phospholipids within the muscle membranes involved in the action of insulin.Keywords
This publication has 40 references indexed in Scilit:
- The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and functionPublished by Elsevier ,2003
- Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by13C Nuclear Magnetic Resonance SpectroscopyNew England Journal of Medicine, 1990
- Early Metabolic Defects in Persons at Increased Risk for Non-Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1989
- Risk Factors for Coronary Artery Disease in Healthy Persons with Hyperinsulinemia and Normal Glucose ToleranceNew England Journal of Medicine, 1989
- Banting lecture 1988. Role of insulin resistance in human diseaseDiabetes, 1988
- Insulin stimulation of glucose uptake can be mediated by diacylglycerol in adipocytesNature, 1988
- Insulin Resistance in Essential HypertensionNew England Journal of Medicine, 1987
- Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglycerideAtherosclerosis, 1985
- Characterization of the insulin resistance of aging.Journal of Clinical Investigation, 1983
- Maintenance of 3T3-L1 cells in culture media containing saturated fatty acids decreases insulin binding and insulin actionBiochemical and Biophysical Research Communications, 1981