Single-dose ciprofloxacin in the treatment of uncomplicated urinary tract infection in women

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Abstract
In a randomised, double-blind trial two single-dose regimens of ciprofloxacin were evaluated for treatment of acute urinary tract infection (UTI) in women. Fifty-three women received 250mg and 46 750mg of ciprofloxacin. Seven days after treatment the eradication rate was 81.1% and 82.6% in the low and high dose groups respectively; the clinical cure rate at 28 days was 64.1% and 73.9% respectively. In women with recurrent UTI a significantly better response was found with the high dose regimen (92% versus 68%; p<0.001). It is concluded that a single 250mg dose of ciprofloxacin is effective for treatment in most women with acute UTI, but in women with recurrent infection a 750mg dose is preferable.