Visual Working Memory Is Impaired when the Medial Temporal Lobe Is Damaged
- 1 July 2006
- journal article
- case report
- Published by MIT Press in Journal of Cognitive Neuroscience
- Vol. 18 (7) , 1087-1097
- https://doi.org/10.1162/jocn.2006.18.7.1087
Abstract
The canonical description of the role of the medial temporal lobes (MTLs) in memory is that short-term forms of memory (e.g., working memory [WM]) are spared when the MTL is damaged, but longer term forms of memory are impaired. Tests used to assess this have typically had a heavy verbal component, potentially allowing explicit rehearsal strategies to maintain the WM trace over the memory delay period. Here we test the hypothesis that the MTL is necessary for visual WM when verbal rehearsal strategies are difficult to implement. In three patients with MTL damage we found impairments in spatial, face, and color WM, at delays as short as 4 sec. Impaired memory could not be attributed to memory load or perceptual problems. These findings suggest that the MTLs are critical for accurate visual WM.Keywords
This publication has 47 references indexed in Scilit:
- Remembering What But Not Where: Independence of Spatial and Visual Working Memory in the Human BrainPublished by Elsevier ,2008
- Spatial memory deficits in patients with lesions to the right hippocampus and to the right parahippocampal cortexNeuropsychologia, 1998
- Learning and transfer of object—reward associations and the role of the perirhinal cortex.Behavioral Neuroscience, 1998
- The human perirhinal cortex and recognition memoryHippocampus, 1998
- Temporal dynamics of brain activation during a working memory taskNature, 1997
- The Psychophysics ToolboxSpatial Vision, 1997
- The animal model of human amnesia: long-term memory impaired and short-term memory intact.Proceedings of the National Academy of Sciences, 1994
- Intact verbal and nonverbal short‐term memory following damage to the human hippocampusHippocampus, 1992
- The Control of Short-Term MemoryScientific American, 1971
- Amnesia and the distinction between long- and short-term memoryJournal of Verbal Learning and Verbal Behavior, 1970