Antibody to Cryptococcus neoformans Glucuronoxylomannan Inhibits the Release of Capsular Antigen
Open Access
- 1 June 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (6) , 3674-3679
- https://doi.org/10.1128/iai.72.6.3674-3679.2004
Abstract
Cryptococcus neoformans releases capsular polysaccharide in the supernatant of liquid cultures and in tissues. Significantly less glucuronoxylomannan (GXM) was released by C. neoformans in the presence of capsule-binding monoclonal antibody (MAb). MAb-mediated inhibition of GXM release may be another mechanism by which humoral immunity can mediate protection against this pathogen.Keywords
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