Determination of Heavy Water (HDO) in Body Fluids by Direct Introduction of Water into a Mass Spectrometer; Measurement of Total Body Water

Abstract
The preparation and analysis of samples and the mathematical relations involved in the use of deuterium oxide (which is distributed chiefly as HDO) for measuring total body water are described. In 27 subjects in whom this procedure was carried out, a relative error of 2.9% in the mean volume of 39.8 1 was found.