Anti‐α4 integrin antibody induces apoptosis in murine thymocytes and staphylococcal enterotoxin B‐activated lymph node T cells
Open Access
- 1 November 1997
- journal article
- research article
- Published by Wiley in Immunology
- Vol. 92 (3) , 321-327
- https://doi.org/10.1046/j.1365-2567.1997.00351.x
Abstract
We have shown that an antibody (9C10) to the α4 integrin induces apoptosis in murine immature CD4+ CD8+ thymocytes and in activated (but not resting) mature lymph node T cells. In both cases, apoptosis is blocked by the highly selective protein kinase C (PKC) inhibitor Ro31.8425, suggesting that 9C10 induces signalling through the α4 integrin resulting in PKC activation leading to apoptosis. Overall, our results indicate the potential role of the α4 integrin-mediated interactions in apoptosis induction during T-cell development and following mature T-cell activation.Keywords
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