Glucose-6-Phosphate Phosphohydrolase Activity in Erythrocytes of Cancer Patients and Blood, Liver, and Brain of Tumor-Bearing Rats
- 1 October 1971
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 47 (4) , 741-745
- https://doi.org/10.1093/jnci/47.4.741
Abstract
Glucose-6-phosphate phosphchydrolcse (G-6-Pase) activity in the red blood cells, liver, and brain of rats bearing experimental Guerin tumors was investigated. G-6-Pase activity decreased in all the tissues from tumor-bearing animals compared to the level of activity found in normal rat tissues. A low G-6-Pase activity was noted in red blood cells of 19 patients with various forms of cancer, as compared to the activity in healthy subjects. G-6-Pase activity was particularly low in patients with cancer of the cervix uteri and uterine body. No significant alterations were found in G-6-Pase activity in the erythrocytes of patients with non-neoplastic disease.Keywords
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