CARONAMIDE FOR INCREASING PENICILLIN PLASMA CONCENTRATIONS IN MAN

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Abstract
A new drug, caronamide,1 when given orally to patients receiving penicillin produces a physiologic and reversible inhibition of the excretion of this antibiotic, which results in elevation of the concentration of penicillin in the plasma. The primary objective of penicillin therapy is the maintenance of therapeutic concentrations of the antibiotic in the body tissues, but there appears to be no general agreement concerning therapeutic concentrations. Nor has it yet been made clear whether the maintenance of a constant level of penicillin plasma concentration is more desirable than the attainment of intermittent and temporary high levels. There does appear to be general agreement, however, that the attainment of high concentrations of penicillin is desirable. It is difficult to attain elevated concentrations because of the rapidity with which penicillin is absorbed from the site of injection and excreted by the kidneys. Efforts have been made to maintain plasma concentrations of the

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