Venous drainage of the femur permits passage of 100-?m particles

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Abstract
Iatrogenic metastasis of bone tumor is reportedly increased if aggregates of tumor cells enter the circulation. The current study used a previously developed animal model to explore the movement of 25‐, 50‐, and 100‐μ‐diameter particles from an experimental femur biopsy site into the circulation. The results indicate that cell aggregate‐sized particles can enter the circulation from the femur at a rate similar to that of the 15‐μm particles used in previous studies. Arterial blood samples collected during and after the injection of particles contained no 50‐ or 100‐μm particles, suggesting that the lung is an effective filter for these larger particles.

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