Tyr‐MIF‐1 attenuates antinociceptive responses induced by three models of stress‐analgesia

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Abstract
Tyr‐MIF‐1 (Tyr‐Pro‐Leu‐Gly‐NH2), a biologically active brain peptide, has previously been shown to antagonize the analgesia induced by morphine. In this report experiments are described in which mice were tested on the hot‐plate in three models of antinociception—shock, novel environment, and warm‐water swim—after the administration of various doses of Tyr‐MIF‐1 without any exogenous opiates. The peptide reduced the antinociception produced by all three methods of inducing endogenous antinociception. These results add further support for the existence of peptides like Tyr‐MIF‐1 that act as opiate antagonists.