A Case of Guillain-Barré Syndrome with Immunologic Abnormalities

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Abstract
Guillain-Barre syndrome and the nephrotic syndrome developed in a patient simultaneously. Analysis of renal biopsy by light, immunofluorescent and electron microscopy showed lipoid nephrosis. T cell lymphocytopenia, lymphocytotoxic antibodies, depressed lymphocyte mitogenesis and anergy complicated the illness. The immunologic abnormalities resolved when the polyradiculoneuritis and lipoid nephrosis remitted. This previously undescribed association illustrates the occurrence of 2 postulated cell-mediated autoimmune disorders despite the presence of depressed cell-mediated immunity.