DETERMINATION OF TYPES OF PNEUMOCOCCUS IN LOBAR PNEUMONIA

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Abstract
In view of the fact that lobar pneumonia is prevalent in military camps in the United States, and that at present it is impossible to obtain white mice in sufficient numbers for carrying out the biologic tests necessary in the determination of types of pneumococcus, a rapid cultural method dispensing with the use of these animals is now proposed. Experience has demonstrated the importance of determining the immunologic type of pneumococcus concerned in the production of each individual case of lobar pneumonia. A satisfactory method for this consists in inoculating a white mouse intraperitoneally with a small amount of sputum, and in recovering the pneumococcus by cultural methods from the heart's blood after the death of the animal. The type of pneumococcus can be determined in this way in about forty-eight hours. When it became evident that specific type pneumococcus serum has distinct therapeutic value, it was necessary to devise

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