The relationship between aberrant methylation and survival in non-small-cell lung cancers
Open Access
- 20 July 2004
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 91 (4) , 771-774
- https://doi.org/10.1038/sj.bjc.6602013
Abstract
The present study examined the relationship between methylation of five genes (p16INK4a, RASSF1A, APC, RARβ and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16INK4a methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.Keywords
This publication has 21 references indexed in Scilit:
- Dose effect of smoking on aberrant methylation in non‐small cell lung cancersInternational Journal of Cancer, 2004
- RASSF1A gene inactivation in non‐small cell lung cancer and its clinical implicationInternational Journal of Cancer, 2003
- Smoke exposure, histologic type and geography‐related differences in the methylation profiles of non‐small cell lung cancerInternational Journal of Cancer, 2002
- Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma.2002
- Prognostic molecular markers in non-small cell lung cancerLung Cancer, 2001
- DNA methylation profiles of lung tumors.2001
- Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epitheliaOncogene, 2000
- Demethylation by 5-aza-2??-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor ?? gene in human colon carcinoma cellsAnti-Cancer Drugs, 1998
- Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.Proceedings of the National Academy of Sciences, 1996
- The retinoblastoma protein and cell cycle controlCell, 1995