Comparison of Adjuvants for an Inactivated Infectious Coryza Vaccine

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Abstract
Differently formulated inactivated infectious coryza vaccines were administered to 6-week-old chickens as a single dose of 108 colony-forming units of Haemophilus paragalliarum HP31. After 3 weeks, all chickens were challenged by intrasinus inoculation of HP31. Two vaccines, one containing an aluminum-hydroxide adjuvant and the other a combined aluminum-hydroxide + mineral-oil adjuvant, gave the best protection (means of 80% and 90%, respectively). Two vaccines that contained mineral oil as the sole adjuvant gave less protection (50% and 35%). The Quil A vaccine gave no significant protection. Granulomatous swellings developed at the site of injection in birds given mineral-oil adjuvant but not in those that received other adjuvants.