The Genetic Program of Hematopoietic Stem Cells
Top Cited Papers
- 2 June 2000
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 288 (5471) , 1635-1640
- https://doi.org/10.1126/science.288.5471.1635
Abstract
Blood cell production originates from a rare population of multipotent, self-renewing stem cells. A genome-wide gene expression analysis was performed in order to define regulatory pathways in stem cells as well as their global genetic program. Subtracted complementary DNA libraries from highly purified murine fetal liver stem cells were analyzed with bioinformatic and array hybridization strategies. A large percentage of the several thousand gene products that have been characterized correspond to previously undescribed molecules with properties suggestive of regulatory functions. The complete data, available in a biological process–oriented database, represent the molecular phenotype of the hematopoietic stem cell.Keywords
This publication has 27 references indexed in Scilit:
- Exploring the new world of the genome with DNA microarraysNature Genetics, 1999
- Histone macroH2A1 is concentrated in the inactive X chromosome of female mammalsNature, 1998
- Regulatory Mechanisms in Stem Cell BiologyCell, 1997
- The Transcriptional Coactivators p300 and CBP Are Histone AcetyltransferasesPublished by Elsevier ,1996
- Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem CellScience, 1996
- Resting and activated subsets of mouse multipotent hematopoietic stem cells.Proceedings of the National Academy of Sciences, 1990
- Cellular and developmental properties of fetal hematopoietic stem cellsCell, 1990
- Clonal and systemic analysis of long-term hematopoiesis in the mouse.Genes & Development, 1990
- Subtractive hybridization system using single-stranded phagemids with directional insertsNucleic Acids Research, 1990
- A simple and very efficient method for generating cDNA librariesGene, 1983