INACTIVATION OF ALPHA-THROMBIN AND BETA-THROMBIN BY ANTITHROMBIN-3 AND HEPARIN

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (3) , 503-508
Abstract
Inactivation of .alpha.- and .beta.-thrombin [bovine] by antithrombin-III and heparin was studied, since it was suggested that 2 forms of thrombin exist with respect to heparin sensitivity. The inactivation rates of .alpha.- and .beta.-thrombin by antithrombin were different, namely .alpha.-thrombin was more sensitive to antithrombin than .beta.-thrombin. Heparin facilitated the complex formation between .alpha.-thrombin and antithrombin-III, but .beta.-thrombin inactivation was only slightly affected. Heparin protected .alpha.-thrombin against the inactivating effect of heat, while .beta.-thrombin lost its activity during the heat treatment. The formation of .beta.-thrombin in blood circulation may have an important role in thrombosis predisposition.

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