HYDROSTATIC-PRESSURE EFFECTS ON DE-SWELLING OF DE-EPITHELIALIZED AND DE-ENDOTHELIALIZED CORNEAS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (7) , 546-550
Abstract
The effect of varying hydrostatic pressure on the thinning rate of preswollen de-epithelialized or de-endothelialized [rabbit] corneas was determined in the specular microscope. The appropriate membrane was removed, the cornea given access to Ringer to swell and then fluid exchange at that surface blocked with oil. De-epithelialized corneas thinned more slowly as hydrostatic pressure on the posterior surface was increased, until fluid movement ceased at 60-70 mm Hg. Fluid movement can occur against a considerable hydrostatic pressure. De-endothelialized corneas thinned at a higher rate as hydrostatic pressure was increased; this effect is probably a mechanical one with increasing pressure forcing fluid out across the epithelium.

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