Interest of Biology in the Management of Pregnancies where a Fetal Malformation Has Been Detected by Ultrasonography
- 1 January 1988
- journal article
- clinical trial
- Published by S. Karger AG in Fetal Diagnosis and Therapy
- Vol. 3 (1-2) , 14-23
- https://doi.org/10.1159/000263329
Abstract
The results of two French collaborative studies are reported with respect to chromosomal and biochemical analyses following the ultrasonographic detection of a fetal anomaly. Overall, chromosomal anomalies were observed in 14.8%, ranging from 8.6% in isolated single malformations to 40.5% in multiple fetal malformations associated with intrauterine growth retardation. Acetylcholinesterase (AChE) electrophoresis was performed on the amniotic fluid of 64 cases of ultrasonographically diagnosed isolated hydrocephalus. 8 cases of previously unsuspected open neural tube defects were diagnosed by AChE. Digestive microvillar enzyme assays were useful in the precise diagnosis of suspected gastrointestinal anomaly. The correlation of the results of ultrasonography and chromosomal and biochemical analyses is the basis for the diagnosis and the prognosis of pregnancy.Keywords
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