Investigation on the enantiomeric impurity of epinephrine hydrochloride injections
- 1 January 1989
- Vol. 1 (1) , 92-93
- https://doi.org/10.1002/chir.530010117
Abstract
Epinephrine enantiomers were derived into diastereoisomers with the chiral reagent 2,3,4,6‐tetra‐O‐acetyl‐β‐D‐glucopyranosylisothiocyanate. The resolutions was carried out on a C18 column. The RS between (−)‐R‐ and (+)‐S‐isomers was 2.3. The retention time could be changed by adding a proper amount of acetonirile into the mobile phase. The results showed that (+)‐S‐isomer in the epinephrine hydrochloride injections increased during the period of storage.Keywords
This publication has 1 reference indexed in Scilit:
- Resolution of enantiomers of norepinephrine and epinephrine by reversed-phase high-performance liquid chromatographyJournal of Chromatography A, 1981