Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function
- 17 August 1987
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 220 (2) , 271-277
- https://doi.org/10.1016/0014-5793(87)80828-1
Abstract
The structures of calcium-activated neutral protease (CANP) and its endogenous inhibitor elucidated recently have revealed novel features with respect to their structure-function relationship and enzyme activity regulation. The protease is regarded as a proenzyme which can be activated at the cell membrane in the presence of Ca2+ and phospholipid, and presumably regulates the functions of proteins, especially membrane-associated proteins, by limited proteolysis. Protein kinase C is hydrolysed and activated by CANP at the cell membrane to a cofactor-independent form. These results are reviewed and the possible involvement of CANP in signal transduction is discussed.Keywords
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