Metabolism in the New Zealand strain of obese mice

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Abstract
A closed-circuit respirometer was devised for measurement of the respiratory exchange in mice. It is particularly suitable for C14-tracer experiments. In the post-absorptive state the New Zealand strain of obese mice has a greater O2 consumption and CO2 production/g body weight than normal mice. New Zealand obese mice oxidize [1-C14 ]- or [2-C14]-acetate at approximately the same rate as controls. The rates of oxidation of both [G-C14]- and [1-C14]-glucose are about 12% lower in the obese than in the normal. The incorporation of C14 derived from [G-C14]-glucose into the glycogen and fatty acids of liver and carcass was determined. Incorporation of C14 into the liver glycogen, but not the carcass glycogen, was considerably less in obese than in normal mice. In several respects the metabolism of the New Zealand strain of obese mice differs from that of the obese strain of the Jackson Memorial Laboratory.