Synthesis and antitumor activity of Pt(II) complexes containing 2,3-diaminopropanol isomers.
- 1 January 1983
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 31 (5) , 1469-1473
- https://doi.org/10.1248/cpb.31.1469
Abstract
Halogeno, sulfato and nitrato Pt(II) complexes of 2,3-diaminopropanol (pnOH) isomers were synthesized and their antitumor activities against leukemia L1210 [mouse cells] were tested. The conformations of the chelate rings were determined to be .lambda.- and .delta.-gauche forms for R- and S-pnOH, respectively, by 13C-NMR and circular dichroism spectral analyses. Among the pnOH isomers, Pt(II) complexes containing R-pnOH showed higher antitumor activity than those containing S- or racemic pnOH. There may be a relationship between the conformations of the chelate rings and antitumor activity in the case of 5-membered chelate rings.This publication has 5 references indexed in Scilit:
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