RECRUDESCENCE OF ANAPLASMA-MARGINALE INDUCED BY IMMUNOSUPPRESSION WITH CYCLOPHOSPHAMIDE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 42  (1) , 19-21
Abstract
Eight doses of cyclophosphamide (5 mg/kg), at 2 day intervals between doses, were administered i.v. to Anaplasma-carrier splenectomized calves. Significant decreases in serum Ig, diminished complement-fixing antibody response and transitory leukopenia were associated with the treatment. Recrudescence of clinical Anaplasma infection occurred after the 5th dose of cyclophosphate was given and was characterized by rapid increase in parasitemia, marked decrease in PCV [packed cell volume] and mortality. Humoral mediated immunity may contribute to the maintenance of equilibrium in the host-parasite relationship and suppression of humoral immune responses may alter the course and outcome of infection in Anaplasma carriers.

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