Cure Stability with Miconazole in Vaginal Candidiasis

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Abstract
The aim of the study was to investigate the stability of the obtained cures after treatment with 2 % Miconazole nitrate vaginal cream as well as to evaluate its therapeutic effects and its tolerance. Fifty three females (mean age 26 years) suffering from vaginal candidiasis were included in the study. Those without positive cultures or those who did not return lor re-examination or were treated with other antimycotic agents were deluded from the study. All patients entered the trial were treated during a first period for their vaginal candidiasis with Miconazole nitrate. Those who were cured the later after two courses of therapy were followed up at monthly intervals until 8 months. Evaluating criteria were the cultures, the microscopic examinations, the subjective symptoms and the objective findings of the investigators. Fifty one patients (96.3 %) were cured after °ne course of treatment (14 days) with Miconazole nitrate and the remaining two, after a second course. The effect of the treatment on the subjective complaints as well as on the objective tindings of the investigators was very satisfactory; 1nd statistically highly significant. Three patients, two on the fifth one on the sixth month relapsed during the follow-up period (relapse rate 5, 6%). From the relapsed cases two had been treated with oral contraceptives for four nionths and the third with trichomonacides for a month. It is concluded thai Miconazole nitrate is an effective and safe anticandidal agent ensuring high cure stability rates in vaginal candidiasis Patients.

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