The Influence of Various Dispersion Methods on the Rate of Dissolution of Sulfabenzamide
- 1 January 1974
- journal article
- research article
- Published by Taylor & Francis in Drug Development Communications
- Vol. 1 (5) , 369-387
- https://doi.org/10.3109/03639047409088185
Abstract
The solvent and melt methods were employed to prepare solid dispersions with various water soluble carriers and a slightly soluble drug, sulfabenzamide. The carriers investigated included citric acid, succinic acid, dextrose, polyethylene glycol 6000, mannitol and urea. Dispersions with dextrose were superior to other carriers in releasing the drug into solution. Melts with both dextrose and urea produced faster rates of dissolution of sulfabenzamide than the coprecipitates from the solvent method. With mannitol and polyethylene glycol 6000, the coprecipitates produced a faster rate of dissolution of the drug than the melt dispersions.This publication has 12 references indexed in Scilit:
- Increased Dissolution Rates of Water-Insoluble Cardiac Glycosides and Steroids via Solid Dispersions in Polyethylene Glycol 6000Journal of Pharmaceutical Sciences, 1971
- Pharmaceutical Applications of Solid Dispersion SystemsJournal of Pharmaceutical Sciences, 1971
- Absorption Characteristics of Solid Dispersed and Micronized Griseofulvin in ManJournal of Pharmaceutical Sciences, 1971
- Oral Absorption of Griseofulvin in Dogs: Increased Absorption via Solid Dispersion - in Polyethylene Glycol 6000Journal of Pharmaceutical Sciences, 1970
- Preparation and Dissolution Characteristics of Several Fast-Release Solid Dispersions of GriseofulvinJournal of Pharmaceutical Sciences, 1969
- Increasing Dissolution Rates and Gastrointestinal Absorption of Drugs Via Solid Solutions and Eutectic Mixtures IVJournal of Pharmaceutical Sciences, 1966
- Increasing Dissolution Rates and Gastrointestinal Absorption of Drugs via solid Solutions and Eutectic mixtures IIJournal of Pharmaceutical Sciences, 1966
- Increasing Dissolution Rates and Gastrointestinal Absorption of Drugs Via Solid Solutions and Eutectic Mixtures IJournal of Pharmaceutical Sciences, 1965
- Enhancement of theInteractionPhysical Review Letters, 1964
- Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man.CHEMICAL & PHARMACEUTICAL BULLETIN, 1961