Abstract
* The 1979 Wright-Schulte Lecture of the International Society for Thrombosis and Haemostasis. Otherwise unpublished studies were supported in part by Grant HL-01661 from the National Heart, Lung and Blood Institute, the National Institutes of Health, U.S. Public Health Service, and in part by grants from the American Heart Association and its Northest Ohio Affiliate. Plenary lecture held at the VIIth International Congress on Thrombosis and Haemostasis, London, 15-20 July, 1979.

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