EFFECT OF LEVAN ON STAGES OF DEVELOPMENT OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 12  (11) , 1294-1297
Abstract
Experimental allergic encephalomyelitis was induced in male N13 guinea pigs by inoculation of an emulsion of basic myelin protein with complete Freund''s adjuvant. The disease was also passively transferred to other animals of the same strain by i.p. injection of sensitized lymphocytes obtained from donors inoculated with the antigenic emulsion 8 days previously. Daily administration of levan markedly reduced the incidence and severity of the disease in actively sensitized animals. Little, if any, effect was obtained by levan treatment of animals with the passively transferred disease. The previously reported inhibitory effect of levan on the development of experimental allergic encephalomyelitis is probably due mainly to a derangement of the afferent path (stage of sensitization). Administration of levan also causes a depletion of lymphocytes in the lymph nodes and this may presumably also affect the efferent path.

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