The ability of induced osteo‐progenitor cells to maintain and rebuild long‐term ectopic osteo‐hematopoietic foci in vitro

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Abstract
Tooth matrix particles were implanted s.c. into mice. In six to nine months, fully developed, induced osteo-hematopoietic foci complete with a cortex and central marrow cavity were formed. The cells from the induced foci were serially retransplanted under the renal capsule of syngeneic recipients. The focus formation was observed during three consecutive passages. The effect was not due to secondary induction. Our data show that the induced osteogenic cells are capable of long-term maintenance, remodeling and recurrent rebuilding of hematopoietic stroma without an additional application of the inductor.