Brief Communication: Inhibition of Tumor Promotion by a Neutral Fraction of Cigarette Smoke Condensate2
- 1 February 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 52 (2) , 613-615
- https://doi.org/10.1093/jnci/52.2.613
Abstract
Cigarette smoke condensate (CSC) and 2 neutral subfractions were applied to mouse skin concurrently with the tumor promoter 12-O-tetradecanoyl phorbol13- acetate (TPA) after initiation with 7,12-dimethylbenz[a] anthracene. The ether-soluble neutral fraction, which has marginal tumor-promoting activity, inhibited the promoting effect of TPA, as measured by a delayed tumor appearance and a reduction in the number of tumor-bearing mice. Neither the benzo[a]pyrene-containing fraction nor crude CSC altered the promoting activity of TPAKeywords
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