Opiate pharmacology and individual differences. II. Somatosensory evoked potentials
- 1 June 1981
- journal article
- research article
- Published by Wolters Kluwer Health in Pain
- Vol. 10 (3) , 367-377
- https://doi.org/10.1016/0304-3959(81)90098-1
Abstract
Somatosensory evoked potentials (EPs) to stimuli ranging from barely perceptible to painful were recorded in 153 normal human adults. Reliability of amplitude and amplitude/intensity slopes were demonstrated in 29 individuals tested twice, 2 or more weeks apart. In randomized, double-blind placebo controlled trials, both aspirin and morphine significantly diminished the N120 component at high stimulus intensities. Age, sex and pharmacological effects paralleled those found with psychophysical techniques in part 1 of this study.Keywords
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