Phosphorylation of hepatic insulin receptor by casein kinase 2
- 9 May 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 232 (1) , 130-134
- https://doi.org/10.1016/0014-5793(88)80401-0
Abstract
Casein kinase 2 was able to phosphorylate the β-subunit of hepatic insulin receptor in the presence of either ATP or GTP. Phosphorylation by casein kinase 2 was observed even in the absence of insulin, was inhibited by low heparin concentrations, and led to the incorporation of phosphate on serine and threonine residues. Casein kinase 2 phosphorylation of insulin receptor partially decreased its tyrosine kinase activity.Keywords
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