Comparisons of Nuclear Antigens of Epstein-Barr Virus (EBV) and EBV-like Simian Viruses

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Abstract
Nuclear antigens (NA) of Epstein-Barr virus (EBV) (EBNA), Herpesvirus [H.] gorilla, H. papio, H. pongo and H. pan were tested with sera of human, gorilla, chimpanzee, orangutan, gibbon and baboon origins. Conventional anticomplement immunofluorescence (ACIF) and acid-fixed nuclear binding of antigen followed by ACIF (AFNB) procedures were used. Comparisons of antibody titers by ACIF and AFNB suggested that human sera detected the same antigenic determinants on EBNA by the 2 procedures but gorilla sera measured different determinants on H. gorilla NA. Asymmetric cross-reactions were found with gorilla, chimpanzee and baboon sera but individual human and orangutan sera were found which had extensive cross-reactivities. Absorption experiments with these broadly reactive sera with H. gorilla NA and comparisons of antibody titers of human sera with EBNA, H. gorilla and H. papio NA suggested that presence of an EBV-specific determinant and a broadly reactive determinant on EBNA.

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