Modulation of Phenotype and Cytoskeleton Architecture by lnterleukin-1 Alpha in Human Osteoblast-Like Cells in vitro

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Abstract
Interleukin-1α, a growth factor produced by macrophages as well as many other types of cells, is able to modulate biosynthetic activities in bone cells. In this work, the authors show that the administration of interleukin-1α to osteoblas-like cells in vitro induces a marked change in cell morphology, which becomes dendritic, with a smaller cellular body and numerous prolongations. The morphological changes are also accompanied by an alterated expression in the pattern of cytoskeleton proteins.

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