MODEL FOR PREDICTION OF CHEMOTHERAPY RESPONSE TO 5-FLUOROURACIL BASED ON DIFFERENTIAL DISTRIBUTION OF 5-[F-18]FLUOROURACIL IN SENSITIVE VERSUS RESISTANT LYMPHOCYTIC-LEUKEMIA IN MICE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (7) , 2306-2308
Abstract
The distribution of 5-[18F]fluorouracil was compared in 2 variants of the same tumor in C57BL .times. DBA/2 F1 mice: solid L1210 lymphocytic leukemia tumor susceptible to 5-fluorouracil treatment and the same tumor, made resistant to the drug over a 34 generation span. Significant differences in 5-[18F]fluorouracil distribution were observed, most notably in the tumor:blood ratios at 12 h postinjection. The drug responsive tumor showed a 20:1 concentration ratio, whereas the drug resistant tumor only had a 4:1 concentration ratio. These differences may be a reflection of similar ratio differences in humans. This technique may allow, by noninvasive quantification of tumor:blood ratios following administration of 5-[18F]-fluorouracil to man, the differentiation of those human tumors that are likely to respond to drug therapy from those in which the response will be minimal or nil.

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