Characterization of an HLA-DR ? pseudogene in the DRw52 supertypic group
- 1 May 1987
- journal article
- research article
- Published by Springer Nature in Immunogenetics
- Vol. 25 (5) , 336-342
- https://doi.org/10.1007/bf00404427
Abstract
The nature of the DR β II pseudogene in a haplo-type of the DRw52 supertypic group was investigated by nucleotide sequence analysis. It revealed several deleterious mutations in the signal sequence and second domain regions in addition to the complete absence of the first domain and adjacent sequences. No expression of DR βII pseudogene mRNA can be detected. The same DR βII pseudogene is probably present in other members of the DRw52 supertypic group. The pattern of mutations in this DR βII pseudogene is different from that observed in the DR β pseudogene of the DRw53 supertypic group, indicating a distinct evolutionary pathway for these two groups of DR haplotypes.Keywords
This publication has 60 references indexed in Scilit:
- Polymorphism of human Ia antigens: gene conversion between two DR β loci results in a new HLA-D/DR specificityNature, 1986
- Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant.The Journal of Experimental Medicine, 1984
- Linkage map of two HLA-SBβ and two HLA-SBα-related genes: an intron in one of the SBβ genes contains a processed pseudogeneCell, 1984
- The class II molecules of the human and murine major histocompatibility complexCell, 1984
- Structure of the murine immune response I-Aβ locus: Sequence of the I-Aβ gene and an adjacent β-chain second domain exonCell, 1983
- The murine Eα immune response geneCell, 1983
- The structure of a mutant H–2 gene suggests that the generation of polymorphism in H–2 genes may occur by gene conversion-like eventsNature, 1983
- Allelic polymorphism and complexity of the genes for HLA-DR β-chains—direct analysis by DNA–DNA hybridizationNature, 1982
- Role of MHC Gene Products in Immune RegulationScience, 1981
- Organization and Expression of Eucaryotic Split Genes Coding for ProteinsAnnual Review of Biochemistry, 1981