MECHANISM FOR THE HYDROPEROXIDE-MEDIATED INACTIVATION OF PROSTACYCLIN SYNTHETASE
- 1 January 1979
- journal article
- research article
- Vol. 53 (6) , 1191-1196
Abstract
Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase in bovine aorta microsome preparations seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical may be important in the modulation of prostacyclin synthesis in diseased states [e.g., platelet-mediated endothelial cell injury].This publication has 9 references indexed in Scilit:
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