MORPHOLOGICAL-CHANGES IN RAT SKELETAL-MUSCLE FOLLOWING RE-INNERVATION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 15  (4) , 333-+
Abstract
Morphological changes appearing in the course of muscle regeneration after reinnervation of denervated M. [musculus] soleus (slow) and M. tibialis anterior (fast) rat skeletal muscle were investigated. Pathological changes typical for denervation atrophy (seen on the 10th day after crushing the sciatic nerve) and symptoms of regeneration (beginning about the 15th day) were more pronounced in the soleus than in the tibialis muscle. Some stages of regeneration in the soleus muscle could be distinguished. The destruction of contractile material was the 1st pathological change that disappeared after the beginning of regeneration. In the 2nd stage other denervation changes disappeared and intensive regeneration of muscle fibers was observed. In the next stage regeneration slowed and the reduction of the excess muscle nuclei was visible. Four months after crushing the nerve, regeneration proceeded to completion with only some traces of the past processes: in the soleus muscle, chains of sarcolemmal nuclei, satellite cells and newly formed muscle fibers were more often seen than in contralateral muscle; in the tibialis, collagen depots were present around the vessels and between muscle fascicles.

This publication has 2 references indexed in Scilit: