Synthesis of some possible metabolites of thyroxine and triiodothyronine
- 1 August 1956
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 63 (4) , 601-605
- https://doi.org/10.1042/bj0630601
Abstract
The acetic acid analogues of thyroxine and triiodo-thyronine were synthesized from p-hydroxyphenylacetic acid. A synthetic route to 3:5-diiodo-4-(3'':4''-dihydroxyphenoxy) phenyl-L-alanine and its 5''-iodo derivative, possible products of the hydrolytic deiodination of triiodothyronine and thyroxine respectively, was explored. The RF values of the iodothyroacetic acids in a number of different solvent systems were compared with those of the corresponding iodothyronines.Keywords
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