Fixed Minidose Warfarin and Aspirin Alone and in Combination vs Adjusted-Dose Warfarin for Stroke Prevention in Atrial Fibrillation
Open Access
- 27 July 1998
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 158 (14) , 1513-1521
- https://doi.org/10.1001/archinte.158.14.1513
Abstract
ATRIAL FIBRILLATION is associated with an overall risk for ischemic stroke of 4.5% per year, which is about 6 times the risk with sinus rhythm.1,2 Seven randomized studies have shown that adjusted-dose oral anticoagulant therapy is effective for primary and secondary prevention of thromboembolic events in patients with nonvalvular atrial fibrillation.3-9 Therefore, anticoagulant therapy with the intensity of the international normalized ratio of prothrombin time (INR) of 2.0 to 3.0 is recommended.10 Antiplatelet therapy seems less effective.This publication has 2 references indexed in Scilit: