Flow parameters associated with hydrodynamic cell injury
- 5 November 1994
- journal article
- research article
- Published by Wiley in Biotechnology & Bioengineering
- Vol. 44 (9) , 1089-1098
- https://doi.org/10.1002/bit.260440910
Abstract
Two flow parameters are proposed for the analysis of flows that have potential to damage animal cells. They are the state of stress (characterized by the second invariant of the stress tensor) and the flow classification parameter RD (which is related to the possibility of stress relaxation). We consider the flow that occurs when a 1.7-mm bubble collapses at a liquid interface. Using these two parameters, we show the regions in which the flow is strong in terms of high hydrodynamic stresses and elongation characteristics. © 1994 John Wiley & Sons, Inc.Keywords
This publication has 61 references indexed in Scilit:
- Gas bubbles bursting at a free surfaceJournal of Fluid Mechanics, 1993
- Biological responses of hybridoma cells to hydrodynamic shear in an agitated bioreactorEnzyme and Microbial Technology, 1991
- Biological responses of hybridoma cells to defined hydrodynamic shear stressJournal of Biotechnology, 1989
- Growth and death rates of bovine embryonic kidney cells in turbulent microcarrier bioreactorsBioprocess and Biosystems Engineering, 1989
- Physical mechanisms of cell damage in microcarrier cell culture bioreactorsBiotechnology & Bioengineering, 1988
- Hydrodynamic effects on cells in agitated tissue culture reactorsBioprocess and Biosystems Engineering, 1986
- The biorheology of tumor cellsBiorheology, 1984
- Apparatus for subjecting living cells to fluid shear stressReview of Scientific Instruments, 1982
- Objective and generally applicable criteria for flow classificationJournal of Non-Newtonian Fluid Mechanics, 1979
- Effect of shear on the death of two strains of mammalian tissue cellsBiotechnology & Bioengineering, 1971