Isolation of mutants deregulated in phosphate control of candicidin biosynthesis.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (6) , 600-606
- https://doi.org/10.7164/antibiotics.32.600
Abstract
Mutants [Streptomyces griseus] were isolated in which phosphate does not inhibit the biosynthesis of candicidin. At high phosphate concentrations, candicidin production by phosphate-deregulated mutants is still inhibited, but to a lesser extent than in the wild type. Some of these mutants are higher candicidin producers than the wild type in phosphate-supplemented medium and also in non-supplemented production medium. The high candicidin production by these mutants is due to a high specific rate of candicidin biosynthesis and an extended production phase. None of the phosphate-deregulated mutants in which uptake of [32P]phosphate was measured was a phosphate-permeability mutant.This publication has 1 reference indexed in Scilit:
- Intracellular cyclic adenosine 3′,5′-monophosphate levels and streptomycin production in cultures of Streptomyces griseusCanadian Journal of Microbiology, 1978